Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

Mammalian mitochondrial DNA (mtDNA) is packaged by mitochondrial transcription factor A (TFAM) into mitochondrial nucleoids that are of key importance in controlling the transmission and expression of mtDNA. Nucleoid ultrastructure is poorly defined, and therefore we used a combination of biochemist...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kukat, Christian, Davies, Karen M., Wurm, Christian A., Spåhr, Henrik, Bonekamp, Nina A., Kühl, Inge, Joos, Friederike, Polosa, Paola Loguercio, Park, Chan Bae, Posse, Viktor, Falkenberg, Maria, Jakobs, Stefan, Kühlbrandt, Werner, Larsson, Nils-Göran
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568684/
https://ncbi.nlm.nih.gov/pubmed/26305956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512131112
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