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Does MtDNA Nucleoid Organization Impact Aging?

Somatic cells in tissue culture package several copies of mitochondrial DNA (mtDNA) in aggregates known as nucleoids that appear to be remarkably stable. The clustering of multiple mtDNA genomes in a single nucleoid complex may promote the progressive age-related accumulation of deletion and point m...

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Detalhes bibliográficos
Autor principal: Bogenhagen, Daniel F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879461/
https://ncbi.nlm.nih.gov/pubmed/20004238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2009.12.002
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