Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication

Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the haplogroup carry functional implications and whic...

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Detalhes bibliográficos
Main Authors: Suissa, Sarit, Wang, Zhibo, Poole, Jason, Wittkopp, Sharine, Feder, Jeanette, Shutt, Timothy E., Wallace, Douglas C., Shadel, Gerald S., Mishmar, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673036/
https://ncbi.nlm.nih.gov/pubmed/19424428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000474
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