Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication

Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the haplogroup carry functional implications and whic...

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Main Authors: Suissa, Sarit, Wang, Zhibo, Poole, Jason, Wittkopp, Sharine, Feder, Jeanette, Shutt, Timothy E., Wallace, Douglas C., Shadel, Gerald S., Mishmar, Dan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673036/
https://ncbi.nlm.nih.gov/pubmed/19424428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000474
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