Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication

Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the haplogroup carry functional implications and whic...

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Autors principals: Suissa, Sarit, Wang, Zhibo, Poole, Jason, Wittkopp, Sharine, Feder, Jeanette, Shutt, Timothy E., Wallace, Douglas C., Shadel, Gerald S., Mishmar, Dan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673036/
https://ncbi.nlm.nih.gov/pubmed/19424428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000474
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