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The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM

Compartmentalized cAMP signaling regulates mitochondrial dynamics, morphology, and oxidative phosphorylation. However, regulators of the mitochondrial cAMP pathway, and its broad impact on organelle function, remain to be explored. Here, we report that Drosophila Prune is a cyclic nucleotide phospho...

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Publicat a:EMBO Rep
Autors principals: Zhang, Fan, Qi, Yun, Zhou, Kiet, Zhang, Guofeng, Linask, Kaari, Xu, Hong
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388618/
https://ncbi.nlm.nih.gov/pubmed/25648146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439636
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