[(125)I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR

[(125)I]Iodo-ASEM, a new radioligand with high affinity and selectivity for α7-nAChRs (K(i) = 0.5 nM; α7/α4β2 = 3,414), has been synthesized in radiochemical yield of 33 ± 6% from the corresponding di-butyltriazene derivative and at high specific radioactivity (1,600 Ci/mmol; 59.2 MBq/μmol). [(125)I...

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Detalles Bibliográficos
Publicado en:Nucl Med Biol
Main Authors: Gao, Yongjun, Mease, Ronnie C., Olson, Thao T., Kellar, Kenneth J., Dannals, Robert F., Pomper, Martin G., Horti, Andrew G.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387010/
https://ncbi.nlm.nih.gov/pubmed/25687449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2014.12.008
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