In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [(125)I]Iodo-ASEM and [(18)F]ASEM as Radiotracers of Homo- and Heteromeric α7 Nicotinic Acetylcholine Receptors

The α7 nicotinic acetylcholine receptor (α7 nAChR) is involved in several cognitive and physiologic processes; its expression levels and patterns change in neurologic and psychiatric diseases, such as schizophrenia and Alzheimer’s disease, which makes it a relevant drug target. Development of select...

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Publicado en:Molecules
Autores principales: Donat, Cornelius K., Hansen, Henrik H., Hansen, Hanne D., Mease, Ronnie C., Horti, Andrew G., Pomper, Martin G., L’Estrade, Elina T., Herth, Matthias M., Peters, Dan, Knudsen, Gitte M., Mikkelsen, Jens D.
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144377/
https://ncbi.nlm.nih.gov/pubmed/32245032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25061425
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