A New Class of Cancer-Associated PTEN Mutations Defined by Membrane Translocation Defects

Phosphatase and tensin homolog (PTEN), which negatively regulates tumorigenic PIP3 signaling, is a commonly mutated tumor suppressor. The majority of cancer-associated PTEN mutations block its essential PIP3 phosphatase activity. However, there is a group of clinically identified PTEN mutations that...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncogene
Egile Nagusiak: Nguyen, Hoai-Nghia, Yang, Jr-Ming, Rahdar, Meghdad, Keniry, Megan, Swaney, Kristen F., Parsons, Ramon, Park, Ben Ho, Sesaki, Hiromi, Devreotes, Peter N., Iijima, Miho
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377315/
https://ncbi.nlm.nih.gov/pubmed/25263454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.293
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak