A New Class of Cancer-Associated PTEN Mutations Defined by Membrane Translocation Defects

Phosphatase and tensin homolog (PTEN), which negatively regulates tumorigenic PIP3 signaling, is a commonly mutated tumor suppressor. The majority of cancer-associated PTEN mutations block its essential PIP3 phosphatase activity. However, there is a group of clinically identified PTEN mutations that...

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Pubblicato in:Oncogene
Autori principali: Nguyen, Hoai-Nghia, Yang, Jr-Ming, Rahdar, Meghdad, Keniry, Megan, Swaney, Kristen F., Parsons, Ramon, Park, Ben Ho, Sesaki, Hiromi, Devreotes, Peter N., Iijima, Miho
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377315/
https://ncbi.nlm.nih.gov/pubmed/25263454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.293
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