PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation

Stimulator of interferon genes (STING, also known as MITA and ERIS) is critical in protecting the host against DNA pathogen invasion. However, the molecular mechanism underlying the regulation of STING remains unclear. Here, we show that PPM1A negatively regulates antiviral signaling by targeting ST...

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Udgivet i:PLoS Pathog
Main Authors: Li, Zexing, Liu, Ge, Sun, Liwei, Teng, Yan, Guo, Xuejiang, Jia, Jianhang, Sha, Jiahao, Yang, Xiao, Chen, Dahua, Sun, Qinmiao
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376777/
https://ncbi.nlm.nih.gov/pubmed/25815785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004783
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