PPM1B negatively regulates antiviral response via dephosphorylating TBK1

The production of type I interferon must be tightly regulated and aberrant production of type I interferon is harmful or even fatal to the host. TBK1 phosphorylation at Ser172 plays an essential role in TBK1-mediated antiviral response. However, how TBK1 activity is negatively regulated remains poor...

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Autors principals: Zhao, Yanling, Liang, Li, Fan, Yihui, Sun, Surong, An, Lei, Shi, Zhongcheng, Cheng, Jin, Jia, Wei, Sun, Wenjing, Mori-Akiyama, Yuko, Zhang, Hong, Fu, Songbin, Yang, Jianhua
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432707/
https://ncbi.nlm.nih.gov/pubmed/22750291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2012.06.017
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