PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1

Cytosolic RNA sensing is a prerequisite for initiation of innate immune response against RNA viral pathogens. Signaling through RIG-I (retinoic acid–inducible gene I)–like receptors (RLRs) to TBK1 (Tank-binding kinase 1)/IKKε (IκB kinase ε) kinases is transduced by mitochondria-associated MAVS (mito...

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Udgivet i:Sci Adv
Main Authors: Xiang, Weiwen, Zhang, Qian, Lin, Xia, Wu, Shiying, Zhou, Yao, Meng, Fansen, Fan, Yunyun, Shen, Tao, Xiao, Mu, Xia, Zongping, Zou, Jian, Feng, Xin-Hua, Xu, Pinglong
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2016
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942338/
https://ncbi.nlm.nih.gov/pubmed/27419230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1501889
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