PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation

Stimulator of interferon genes (STING, also known as MITA and ERIS) is critical in protecting the host against DNA pathogen invasion. However, the molecular mechanism underlying the regulation of STING remains unclear. Here, we show that PPM1A negatively regulates antiviral signaling by targeting ST...

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Опубликовано в: :PLoS Pathog
Главные авторы: Li, Zexing, Liu, Ge, Sun, Liwei, Teng, Yan, Guo, Xuejiang, Jia, Jianhang, Sha, Jiahao, Yang, Xiao, Chen, Dahua, Sun, Qinmiao
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376777/
https://ncbi.nlm.nih.gov/pubmed/25815785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004783
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