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Structural basis of STING binding with and phosphorylation by TBK1
The invasion of mammalian cytoplasm by microbial DNA from infectious pathogens or by self DNA from the nucleus or mitochondria represents a danger signal that alerts the host immune system(1). Cyclic GMP–AMP synthase is a sensor of cytoplasmic DNA that activates the type-I interferon pathway(2). Upo...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6862768/ https://ncbi.nlm.nih.gov/pubmed/30842653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1000-2 |
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