Structural basis of STING binding with and phosphorylation by TBK1

The invasion of mammalian cytoplasm by microbial DNA from infectious pathogens or by self DNA from the nucleus or mitochondria represents a danger signal that alerts the host immune system(1). Cyclic GMP–AMP synthase is a sensor of cytoplasmic DNA that activates the type-I interferon pathway(2). Upo...

Full description

Saved in:

Bibliographic Details
Published in:	Nature
Main Authors:	Zhang, Conggang, Shang, Guijun, Gui, Xiang, Zhang, Xuewu, Bai, Xiao-chen, Chen, Zhijian J.
Format:	Artigo
Language:	Inglês
Published:	2019
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6862768/ https://ncbi.nlm.nih.gov/pubmed/30842653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1000-2
Tags:	Add Tag No Tags, Be the first to tag this record!

Structural basis of STING binding with and phosphorylation by TBK1

Similar Items