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Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1
The innate immune protein Stimulator of interferon genes (STING) promotes the induction of interferon beta (IFN-β) production via the phosphorylation of its C-terminal tail (CTT) by TANK-binding kinase 1 (TBK1). Potent ligands of STING are, therefore, promising candidates for novel anti-cancer drugs...
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| Publicat a: | EBioMedicine |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4972534/ https://ncbi.nlm.nih.gov/pubmed/27333035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.05.039 |
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