Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1

The innate immune protein Stimulator of interferon genes (STING) promotes the induction of interferon beta (IFN-β) production via the phosphorylation of its C-terminal tail (CTT) by TANK-binding kinase 1 (TBK1). Potent ligands of STING are, therefore, promising candidates for novel anti-cancer drugs...

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Detalles Bibliográficos
Publicado en:EBioMedicine
Main Authors: Tsuchiya, Yuko, Jounai, Nao, Takeshita, Fumihiko, Ishii, Ken J., Mizuguchi, Kenji
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972534/
https://ncbi.nlm.nih.gov/pubmed/27333035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.05.039
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