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Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
Infections by pathogens that contain DNA trigger the production of type-I interferons and inflammatory cytokines through the DNA-sensing enzyme cyclic GMP–AMP synthase, which produces 2′3′-cyclic GMP–AMP (cGAMP) that binds to and activates stimulator of interferon genes (STING; also known as TMEM173...
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| Veröffentlicht in: | Nature |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6859894/ https://ncbi.nlm.nih.gov/pubmed/30842659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-0998-5 |
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