A carregar...
Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex
Insulin signaling controls metabolic homeostasis. Here, we report the cryo-EM structure of full-length insulin receptor (IR) and insulin complex in the active state. This structure unexpectedly reveals that maximally four insulins can bind the ‘T’-shaped IR dimer at four distinct sites related by 2-...
Na minha lista:
| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6721835/ https://ncbi.nlm.nih.gov/pubmed/31436533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48630 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|