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Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex
Insulin signaling controls metabolic homeostasis. Here, we report the cryo-EM structure of full-length insulin receptor (IR) and insulin complex in the active state. This structure unexpectedly reveals that maximally four insulins can bind the ‘T’-shaped IR dimer at four distinct sites related by 2-...
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| Yayımlandı: | eLife |
|---|---|
| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
eLife Sciences Publications, Ltd
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6721835/ https://ncbi.nlm.nih.gov/pubmed/31436533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48630 |
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