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Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

RET is a receptor tyrosine kinase (RTK) that plays essential roles in development and has been implicated in several human diseases. Different from most of RTKs, RET requires not only its cognate ligands but also co-receptors for activation, the mechanisms of which remain unclear due to lack of high...

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Podrobná bibliografie
Vydáno v:eLife
Hlavní autoři: Li, Jie, Shang, Guijun, Chen, Yu-Ju, Brautigam, Chad A, Liou, Jen, Zhang, Xuewu, Bai, Xiao-chen
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760901/
https://ncbi.nlm.nih.gov/pubmed/31535977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47650
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