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Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex
The GIPC family adaptor proteins mediate endocytosis by tethering cargo proteins to the myosin VI motor. The structural mechanisms for the GIPC/cargo and GIPC/myosin VI interactions remained unclear. PlexinD1, a transmembrane receptor that regulates neuronal and cardiovascular development, is a carg...
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| Veröffentlicht in: | eLife |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5461112/ https://ncbi.nlm.nih.gov/pubmed/28537552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27322 |
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