Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex

The GIPC family adaptor proteins mediate endocytosis by tethering cargo proteins to the myosin VI motor. The structural mechanisms for the GIPC/cargo and GIPC/myosin VI interactions remained unclear. PlexinD1, a transmembrane receptor that regulates neuronal and cardiovascular development, is a carg...

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Bibliographic Details
Published in:eLife
Main Authors: Shang, Guijun, Brautigam, Chad A, Chen, Rui, Lu, Defen, Torres-Vázquez, Jesús, Zhang, Xuewu
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Biophysics and Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461112/
https://ncbi.nlm.nih.gov/pubmed/28537552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27322
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