Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme

Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type two diabetes, Alzheimer's, inflammation, and other human diseases. However, the process through which IDE recognizes peptides that tend to form amyloid fibrils remained unsolved. We used cryoEM to understand both...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Zhang, Zhening, Liang, Wenguang G, Bailey, Lucas J, Tan, Yong Zi, Wei, Hui, Wang, Andrew, Farcasanu, Mara, Woods, Virgil A, McCord, Lauren A, Lee, David, Shang, Weifeng, Deprez-Poulain, Rebecca, Deprez, Benoit, Liu, David R, Koide, Akiko, Koide, Shohei, Kossiakoff, Anthony A, Li, Sheng, Carragher, Bridget, Potter, Clinton S, Tang, Wei-Jen
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910022/
https://ncbi.nlm.nih.gov/pubmed/29596046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33572
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