Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme

Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type two diabetes, Alzheimer's, inflammation, and other human diseases. However, the process through which IDE recognizes peptides that tend to form amyloid fibrils remained unsolved. We used cryoEM to understand both...

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Pubblicato in:eLife
Autori principali: Zhang, Zhening, Liang, Wenguang G, Bailey, Lucas J, Tan, Yong Zi, Wei, Hui, Wang, Andrew, Farcasanu, Mara, Woods, Virgil A, McCord, Lauren A, Lee, David, Shang, Weifeng, Deprez-Poulain, Rebecca, Deprez, Benoit, Liu, David R, Koide, Akiko, Koide, Shohei, Kossiakoff, Anthony A, Li, Sheng, Carragher, Bridget, Potter, Clinton S, Tang, Wei-Jen
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Structural Biology and Molecular Biophysics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910022/
https://ncbi.nlm.nih.gov/pubmed/29596046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33572
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