Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation

Cytosolic RNA/DNA sensing elicits primary defense against viral pathogens. Interferon regulatory factor 3 (IRF3), a key signal mediator/transcriptional factor of the antiviral-sensing pathway, is indispensible for interferon production and antiviral defense. However, how the status of IRF3 activatio...

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Vydáno v:Genes Dev
Hlavní autoři: Meng, Fansen, Zhou, Ruyuan, Wu, Shiying, Zhang, Qian, Jin, Qiuheng, Zhou, Yao, Plouffe, Steven W., Liu, Shengduo, Song, Hai, Xia, Zongping, Zhao, Bin, Ye, Sheng, Feng, Xin-Hua, Guan, Kun-Liang, Zou, Jian, Xu, Pinglong
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863739/
https://ncbi.nlm.nih.gov/pubmed/27125670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.277533.116
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