Ppm1b negatively regulates necroptosis through dephosphorylating Rip3

The auto-phosphorylation of murine receptor-interacting protein 3 (Rip3) on Thr 231 and Ser 232 in the necrosome is required to trigger necroptosis. However, how Rip3 phosphorylation is regulated is still largely unknown. Here we identified protein phosphatase 1B (Ppm1b) as a Rip3 phosphatase and fo...

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Veröffentlicht in:Nat Cell Biol
Hauptverfasser: Chen, Wanze, Wu, Jianfeng, Li, Lisheng, Zhang, Zhengmao, Ren, Junming, Liang, Yaoji, Chen, Fenfang, Yang, Chao, Zhou, Zhenru, Su, Sheng Sean, Zheng, Xinru, Zhang, Zhirong, Zhong, Chuan-Qi, Wan, Haoqiang, Xiao, Mu, Lin, Xia, Feng, Xin-Hua, Han, Jiahuai
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523090/
https://ncbi.nlm.nih.gov/pubmed/25751141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3120
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