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Sequence of Gating Charge Movement and Pore Gating in hERG Activation and Deactivation Pathways

K(V)11.1 voltage-gated K(+) channels are noted for unusually slow activation, fast inactivation, and slow deactivation kinetics, which tune channel activity to provide vital repolarizing current during later stages of the cardiac action potential. The bulk of charge movement in human ether-a-go-go-r...

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Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Goodchild, Samuel J., Macdonald, Logan C., Fedida, David
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375626/
https://ncbi.nlm.nih.gov/pubmed/25809256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.02.014
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