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Proline Scan of the hERG Channel S6 Helix Reveals the Location of the Intracellular Pore Gate
In Shaker-like channels, the activation gate is formed at the bundle crossing by the convergence of the inner S6 helices near a conserved proline-valine-proline motif, which introduces a kink that allows for electromechanical coupling with voltage sensor motions via the S4-S5 linker. Human ether-a-g...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4026777/ https://ncbi.nlm.nih.gov/pubmed/24606930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.01.035 |
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