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Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype
The hERG channel is a key player in repolarization of the cardiac action potential. Pharmacological blockade of hERG channels depletes the cardiac repolarization reserve, increasing the risk of cardiac arrhythmias. The promiscuous nature of drug interactions with hERG presents a therapeutic challeng...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5862968/ https://ncbi.nlm.nih.gov/pubmed/29563525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23346-x |
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