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Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation
hERG channels underlie the delayed-rectifier K(+) channel current (I(Kr)), which is crucial for membrane repolarization and therefore termination of the cardiac action potential. hERG channels display unusually slow deactivation gating, which contributes to a resurgent current upon repolarization an...
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| Опубликовано в: : | J Gen Physiol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Rockefeller University Press
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6363419/ https://ncbi.nlm.nih.gov/pubmed/30530765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812137 |
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