Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker

Slow deactivation of hERG channels is critical for preventing cardiac arrhythmia yet the mechanistic basis for the slow gating transition is unclear. Here, we characterized the temporal sequence of events leading to voltage sensor stabilization upon membrane depolarization. Progressive increase in s...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Biophys J
Главные авторы: Thouta, Samrat, Hull, Christina M., Shi, Yu Patrick, Sergeev, Valentine, Young, James, Cheng, Yen M., Claydon, Thomas W.
Формат: Artigo
Язык:Inglês
Опубликовано: The Biophysical Society 2017
Предметы:
Channels and Transporters
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266146/
https://ncbi.nlm.nih.gov/pubmed/28122216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.12.021
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы