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Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker
Slow deactivation of hERG channels is critical for preventing cardiac arrhythmia yet the mechanistic basis for the slow gating transition is unclear. Here, we characterized the temporal sequence of events leading to voltage sensor stabilization upon membrane depolarization. Progressive increase in s...
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| Publié dans: | Biophys J |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Biophysical Society
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5266146/ https://ncbi.nlm.nih.gov/pubmed/28122216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.12.021 |
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