Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker

Slow deactivation of hERG channels is critical for preventing cardiac arrhythmia yet the mechanistic basis for the slow gating transition is unclear. Here, we characterized the temporal sequence of events leading to voltage sensor stabilization upon membrane depolarization. Progressive increase in s...

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Bibliografiset tiedot
Julkaisussa:Biophys J
Päätekijät: Thouta, Samrat, Hull, Christina M., Shi, Yu Patrick, Sergeev, Valentine, Young, James, Cheng, Yen M., Claydon, Thomas W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Biophysical Society 2017
Aiheet:
Channels and Transporters
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266146/
https://ncbi.nlm.nih.gov/pubmed/28122216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.12.021
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