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Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype
The hERG channel is a key player in repolarization of the cardiac action potential. Pharmacological blockade of hERG channels depletes the cardiac repolarization reserve, increasing the risk of cardiac arrhythmias. The promiscuous nature of drug interactions with hERG presents a therapeutic challeng...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5862968/ https://ncbi.nlm.nih.gov/pubmed/29563525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23346-x |
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