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Proline Scan of the hERG Channel S6 Helix Reveals the Location of the Intracellular Pore Gate

In Shaker-like channels, the activation gate is formed at the bundle crossing by the convergence of the inner S6 helices near a conserved proline-valine-proline motif, which introduces a kink that allows for electromechanical coupling with voltage sensor motions via the S4-S5 linker. Human ether-a-g...

詳細記述

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書誌詳細
主要な著者: Thouta, Samrat, Sokolov, Stanislav, Abe, Yuki, Clark, Sheldon J., Cheng, Yen M., Claydon, Tom W.
フォーマット: Artigo
言語:Inglês
出版事項: The Biophysical Society 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026777/
https://ncbi.nlm.nih.gov/pubmed/24606930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.01.035
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