NS1643 Interacts around L529 of hERG to Alter Voltage Sensor Movement on the Path to Activation

Activators of hERG1 such as NS1643 are being developed for congenital/acquired long QT syndrome. Previous studies identify the neighborhood of L529 around the voltage-sensor as a putative interacting site for NS1643. With NS1643, the V(1/2) of activation of L529I (−34 ± 4 mV) is similar to wild-type...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Guo, Jiqing, Cheng, Yen May, Lees-Miller, James P., Perissinotti, Laura L., Claydon, Tom W., Hull, Christina M., Thouta, Samrat, Roach, Daniel E., Durdagi, Serdar, Noskov, Sergei Y., Duff, Henry J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Channels and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375528/
https://ncbi.nlm.nih.gov/pubmed/25809253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.12.055
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados