AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Mitochondrial respiration is a crucial component of cellular metabolism that can become dysregulated in cancer. Compared with normal hematopoietic cells, acute myeloid leukemia (AML) cells and patient samples have higher mitochondrial mass, without a concomitant increase in respiratory chain complex...

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Publicado en:Blood
Autores principales: Sriskanthadevan, Shrivani, Jeyaraju, Danny V., Chung, Timothy E., Prabha, Swayam, Xu, Wei, Skrtic, Marko, Jhas, Bozhena, Hurren, Rose, Gronda, Marcela, Wang, Xiaoming, Jitkova, Yulia, Sukhai, Mahadeo A., Lin, Feng-Hsu, Maclean, Neil, Laister, Rob, Goard, Carolyn A., Mullen, Peter J., Xie, Stephanie, Penn, Linda Z., Rogers, Ian M., Dick, John E., Minden, Mark D., Schimmer, Aaron D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2015
Materias:
Myeloid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375109/
https://ncbi.nlm.nih.gov/pubmed/25631767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-594408
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