Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5′-triphosphate analogues at the human P2Y(2) and P2Y(4) receptors

With the long-term goal of developing receptor subtype-selective high affinity agonists for the uracil nucleotide-activated P2Y receptors we have carried out a series of structure activity and molecular modeling studies of the human P2Y(2) and P2Y(4) receptors. UTP analogues with substitutions in th...

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Vydáno v:Biochem Pharmacol
Hlavní autoři: Jacobson, Kenneth A., Costanzi, Stefano, Ivanov, Andrei A., Tchilibon, Susanna, Besada, Pedro, Gao, Zhan-Guo, Maddileti, Savitri, Harden, T. Kendall
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374482/
https://ncbi.nlm.nih.gov/pubmed/16359641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2005.11.010
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