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Structure Activity Relationship of Uridine 5′-Diphosphoglucose (UDP-Glucose) Analogues as Agonists of the Human P2Y(14) Receptor

UDP-glucose (UDPG) and derivatives are naturally-occurring agonists of the G(i) protein-coupled P2Y(14) receptor, which occurs in the immune system. We synthesized and characterized pharmacologically novel analogues of UDPG modified on the nucleobase, ribose, and glucose moieties, as the basis for d...

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Detalhes bibliográficos
Main Authors: Ko, Hyojin, Fricks, Ingrid, Ivanov, Andrei A., Harden, T. Kendall, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408610/
https://ncbi.nlm.nih.gov/pubmed/17407275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061222w
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