Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and L-α-threofuranosyl ring systems: interactions with P2Y receptors

The ribose moiety of adenine nucleotide 3′,5′-bisphosphate antagonists of the P2Y(1) receptor has been successfully substituted with a rigid methanocarba ring system, leading to the conclusion that the North (N) ring conformation is preferred in receptor binding. Similarly, at P2Y(2) and P2Y(4) rece...

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Hauptverfasser: Ohno, Michihiro, Costanzi, Stefano, Kim, Hak Sung, Kempeneers, Veerle, Vastmans, Karen, Herdewijn, Piet, Maddileti, Savitri, Gao, Zhan-Guo, Harden, T. Kendall, Jacobson, Kenneth A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402881/
https://ncbi.nlm.nih.gov/pubmed/15465340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2004.07.067
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