Molecular Modeling of the Human P2Y(2) Receptor and Design of a Selective Agonist, 2′-Amino-2′-deoxy-2-thio-UTP

A rhodopsin-based homology model of the nucleotide-activated human P2Y(2) receptor, including loops, termini, and phospholipids, was optimized with Monte Carlo Multiple Minimum. Docked UTP formed a nucleobase π–π complex with conserved Phe3.32. Selectivity-enhancing 2′-amino-2′-deoxy substitution in...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ivanov, Andrei A., Ko, Hyojin, Cosyn, Liesbet, Maddileti, Savitri, Besada, Pedro, Fricks, Ingrid, Costanzi, Stefano, Harden, T. Kendall, Van Calenbergh, Serge, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404812/
https://ncbi.nlm.nih.gov/pubmed/17302398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060903o
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados