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Molecular Modeling of the Human P2Y(2) Receptor and Design of a Selective Agonist, 2′-Amino-2′-deoxy-2-thio-UTP
A rhodopsin-based homology model of the nucleotide-activated human P2Y(2) receptor, including loops, termini, and phospholipids, was optimized with Monte Carlo Multiple Minimum. Docked UTP formed a nucleobase π–π complex with conserved Phe3.32. Selectivity-enhancing 2′-amino-2′-deoxy substitution in...
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| Glavni autori: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3404812/ https://ncbi.nlm.nih.gov/pubmed/17302398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060903o |
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