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HIV enhancing activity of semen impairs the antiviral efficacy of microbicides

Topically applied microbicides potently inhibit HIV in vitro but have largely failed to exert protective effects in clinical trials. One possible reason for this discrepancy is that the preclinical testing of microbicides does not faithfully reflect the conditions of HIV sexual transmission. Here, w...

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Détails bibliographiques
Publié dans:Sci Transl Med
Auteurs principaux: Zirafi, Onofrio, Kim, Kyeong-Ae, Roan, Nadia R., Kluge, Silvia F., Müller, Janis A., Jiang, Shibo, Mayer, Benjamin, Greene, Warner C., Kirchhoff, Frank, Münch, Jan
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372245/
https://ncbi.nlm.nih.gov/pubmed/25391483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3009634
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