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HIV enhancing activity of semen impairs the antiviral efficacy of microbicides

Topically applied microbicides potently inhibit HIV in vitro but have largely failed to exert protective effects in clinical trials. One possible reason for this discrepancy is that the preclinical testing of microbicides does not faithfully reflect the conditions of HIV sexual transmission. Here, w...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Zirafi, Onofrio, Kim, Kyeong-Ae, Roan, Nadia R., Kluge, Silvia F., Müller, Janis A., Jiang, Shibo, Mayer, Benjamin, Greene, Warner C., Kirchhoff, Frank, Münch, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372245/
https://ncbi.nlm.nih.gov/pubmed/25391483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3009634
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