Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators

Alternative splicing (AS) dramatically expands the complexity of the mammalian brain transcriptome, but its atlas remains incomplete. Here we performed deep mRNA sequencing of mouse cortex to discover and characterize alternative exons with potential functional significance. Our analysis expands the...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Yan, Qinghong, Weyn-Vanhentenryck, Sebastien M., Wu, Jie, Sloan, Steven A., Zhang, Ye, Chen, Kenian, Wu, Jia Qian, Barres, Ben A., Zhang, Chaolin
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371929/
https://ncbi.nlm.nih.gov/pubmed/25737549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502849112
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