Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19

AIM: Conducting PK studies in pregnant women is challenging. Therefore, we asked if a physiologically-based pharmacokinetic (PBPK) model could be used to predict the disposition in pregnant women of drugs cleared by multiple CYP enzymes. METHODS: We expanded and verified our previously published pre...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Ke, Alice Ban, Nallani, Srikanth C, Zhao, Ping, Rostami-Hodjegan, Amin, Unadkat, Jashvant D
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
Drugs in Pregnancy and Lactation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371535/
https://ncbi.nlm.nih.gov/pubmed/23834474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12207
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