A PBPK Model to Predict Disposition of CYP3A-Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction

Besides logistical and ethical concerns, evaluation of safety and efficacy of medications in pregnant women is complicated by marked changes in pharmacokinetics (PK) of drugs. For example, CYP3A activity is induced during the third trimester (T(3)). We explored whether a previously published physiol...

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Detalhes bibliográficos
Main Authors: Ke, A B, Nallani, S C, Zhao, P, Rostami-Hodjegan, A, Unadkat, J D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606941/
https://ncbi.nlm.nih.gov/pubmed/23835883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.2
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