Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment

AIMS: To investigate the influence of different cytochrome P450 (CYP) activities and other potential covariates on the disposition of methadone in patients on methadone maintenance therapy (MMT). METHODS: Eighty-eight patients (58 male; 21–55 years; 84 White) on MMT were studied. CYP2D6 activity [3...

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Detalhes bibliográficos
Main Authors: Shiran, Mohammad-Reza, Lennard, Martin S, Iqbal, Mohammad-Zafar, Lagundoye, Oldwale, Seivewright, Nicholas, Tucker, Geoffrey T, Rostami-Hodjegan, Amin
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668081/
https://ncbi.nlm.nih.gov/pubmed/19133059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03312.x
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