Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism

AIMS: We evaluated the involvement of cytochrome P450 (CYP) isoforms 2C9 and 2C19 in chlorpropamide 2-hydroxylation in vitro and in chlorpropamide disposition in vivo. METHODS: To identify CYP isoforms(s) that catalyse 2-hydroxylation of chlorpropamide, the incubation studies were conducted using hu...

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Bibliographic Details
Main Authors: Shon, Ji-Hong, Yoon, Young-Ran, Kim, Min-Jung, Kim, Kyoung-Ah, Lim, Young-Chae, Liu, Kwang-Hyeon, Shin, Dong-Hoon, Lee, Chung Han, Cha, In-June, Shin, Jae-Gook
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2005
Subjects:
Pharmacogenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884838/
https://ncbi.nlm.nih.gov/pubmed/15842554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02364.x
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