Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation, and is dependent on K(+) efflux

Although neutrophils are the most abundant cells in acute infection and inflammation, relatively little attention has been paid to their role in inflammasome formation and IL-1β processing. In the current study, we investigated the mechanism by which neutrophils process IL-1β in response to Streptoc...

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Publicado no:J Immunol
Main Authors: Karmakar, Mausita, Katsnelson, Michael, Malak, Hesham A., Greene, Neil G., Howell, Scott J., Hise, Amy G., Camilli, Andrew, Kadioglu, Aras, Dubyak, George R., Pearlman, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369676/
https://ncbi.nlm.nih.gov/pubmed/25609842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401624
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