Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

Pneumolysin (PLY) is a key Streptococcus pneumoniae virulence factor and potential candidate for inclusion in pneumococcal subunit vaccines. Dendritic cells (DC) play a key role in the initiation and instruction of adaptive immunity, but the effects of PLY on DC have not been widely investigated. En...

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Main Authors: McNeela, Edel A., Burke, Áine, Neill, Daniel R., Baxter, Cathy, Fernandes, Vitor E., Ferreira, Daniela, Smeaton, Sarah, El-Rachkidy, Rana, McLoughlin, Rachel M., Mori, Andres, Moran, Barry, Fitzgerald, Katherine A., Tschopp, Jurg, Pétrilli, Virginie, Andrew, Peter W., Kadioglu, Aras, Lavelle, Ed C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978728/
https://ncbi.nlm.nih.gov/pubmed/21085613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001191
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